Scientist, Proteomics

Overview: The Translational Research Team at Alnylam is seeking a highly motivated Proteomics Scientist to join our LC/MS-based ‘omics group dedicated to advancing RNAi therapeutics through preclinical target validation, biomarker discovery, and innovation of novel delivery solutions for our RNAi therapeutics. The successful candidate will have a strong theoretical foundation in mass spectrometry and the skills needed to develop state-of-the-art workflows in spatial, single-cell, and subcellular proteomics from sample preparation through data analysis and interpretation. The individual will have excellent collaboration and communication skills to succeed in a fast-paced matrixed environment. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities: Drive sample preparation and LC/MS method development for novel experimental workflows including single cell, spatial, and subcellular proteomics using state-of-the-art instrumentation. Develop novel data analysis and interpretation workflows optimized for next-generation proteomics technologies. Collaborate with an interdisciplinary team focused on identifying and characterizing novel receptors to unlock targeted delivery into new cell types and tissues. Leverage AI tools to inform novel receptor prediction based on protein sequence and structure. Maintain timely documentation and transparently communicate results with key stakeholders throughout the organization. Qualifications: PhD in Bioengineering, Chemical Engineering, or related quantitative field. 0-3 years of experience in biopharma setting. Expertise in LC/MS instrumentation and proteomics method development. Experience with Thermo Orbitrap is a plus. Strong computational background with proficiency in Python, Matlab or R. Experience with cloud computing and/or high-performance compute environments is preferred. Excellent communication skills (both written and oral) are essential. Must be self-motivated and thrive in a fast-paced team environment. Familiarity with high-throughput sample preparation automation is preferred. Strong abilities to work both independently and in a team environment. Intellectual curiosity, a passion for science, critical thinking skills, and a willingness to ask questions. About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.