Sr. Director, HCP TTR Marketing

Overview The Senior Director, HCP Marketing, US TTR, will lead HCP marketing strategy and execution across AMVUTTRA (vutrisiran), ONPATTRO (patisiran), and TTR disease education. This leader will oversee branded marketing, digital and non-personal promotion, medical education marketing, speaker programs, and congress engagement; lead and develop a team of 8 to 10 marketers; and serve as a core member of the US TTR Marketing leadership team, reporting to the Vice President, US TTR Marketing. The ideal candidate is a strategic, customer-focused commercial leader with a strong record of building high-performing teams, translating insights into clear choices, and delivering integrated HCP engagement in a complex and competitive market. Key Responsibilities Lead US HCP marketing strategy across AMVUTTRA, ONPATTRO, and TTR disease education, setting clear portfolio priorities and identifying growth opportunities in polyneuropathy and cardiomyopathy. Oversee development and execution of insight-driven branded marketing and unbranded disease education across personal and non-personal channels. Advance an integrated HCP omnichannel strategy using customer insights, behavioral data, channel performance, and field feedback to improve segmentation, content, and engagement. Lead medical education marketing, including speaker bureau strategy, speaker program optimization, peer-to-peer education, and congress planning and activation. Develop differentiated, patient-centered market development, diagnostic, and competitive strategies that support appropriate HCP engagement and portfolio growth. Engage appropriately with external experts and priority HCP customers to deepen customer understanding and inform commercial strategy. Lead annual planning, operating plans, budgets, investment prioritization, agency partnerships, execution governance, and performance reviews. Define and monitor meaningful performance indicators, using results to optimize strategy, tactics, investment, and channel mix. Lead, coach, and develop a team of HCP marketers, fostering a high-performing culture grounded in accountability, collaboration, inclusion, and development. Build strong partnerships across Global Marketing, Medical, Sales, Market Access, Insights, Omnichannel, Business Operations, Clinical, Legal, Regulatory, and Compliance to enable aligned, efficient, and compliant execution. Qualifications Bachelor's degree required; MBA or relevant advanced degree preferred. 12 or more years of healthcare or biopharmaceutical industry experience, including marketing or other US commercial roles of increasing responsibility. Experience leading marketing for a specialty or biotechnology product in a competitive market; experience in rare disease, cardiology, neurology, amyloidosis, or HCP-administered therapies preferred. Experience across branded HCP promotion, disease education, digital or non-personal promotion, and medical education marketing, including speaker programs or congress strategy. US product launch or major indication-expansion experience strongly preferred. Proven success translating customer, market, and performance insights into differentiated strategies, investment priorities, and measurable execution plans. Demonstrated people leadership, executive presence, cross-functional influence, and ability to lead effectively in a matrixed environment. Experience managing agencies, vendors, promotional budgets, and complex review processes within legal, regulatory, and compliance requirements. About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality. Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Before applying, please review Alnylam's ⁠Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment. #LI-ST1 #LI-Hybrid The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers U.S. Pay Range $233,800 — $316,300 USD